Among the different types of autoantibodies, anti-Hu autoantibodies have been identified to play a crucial role in the pathogenesis of paraneoplastic neuropathies and represent a useful diagnostic marker in the early diagnosis of these disorders since they recognize a family of RNA-binding proteins (HuD, HuC, Hel-N1, and Hel-N2) expressed in the nuclei of neurons and cancer cells which are initially driven to control tumor growth but later misdirected and cause the neurological damage [10]. This evidence concerns the gene ELAVL2 and cancer.