Two established surrogates of endothelial pathology, flow-mediated dilation [17], and circulating soluble adhesion molecule (ICAM-1) [18–22] are highly linked to established cardiovascular risk factors [17, 18, 20–22] and have recently been reported to be strong predictors of T2DM [23]. This evidence concerns the gene ICAM1 and type 2 diabetes mellitus.