PPARGC1A and obesity due to melanocortin 4 receptor deficiency: PPARγ and ERRα activate the transcription of a broad range of genes that control glucose uptake, glycolysis, fatty acid oxidation, TCA cycle, OXPHOS, mitochondrial biogenesis, and uncoupling; thus, the treatments and drugs that can depress NCoRs activity or enhance PGC-1α activity are hoped to prevent obesity and insulin resistance (Figure 3).