Upregulation of liver PPAR-γ can be achieved by a ligand-dependent process including LCPUFA n-3 binding [106]; however, this mechanism does not seem to play a role in obesity-induced PPAR-γ activation due to the substantial depletion of LCPUFA n-3 reported [51, 69, 70]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.