ADIPOQ and metabolic dysfunction-associated steatotic liver disease: In addition to the prosteatotic mechanism underlying NAFLD with development of oxidative stress and LCPUFA n-3 depletion triggering liver SREBP-1c upregulation and PPAR-α downregulation (Figure 1A), alterations in the signaling pathway of adiponectin may also play a role [70, 87] (Figure 1B).