While p53 mutations are present in all types of skin cancer, they are less common in melanoma than in BCCs and SCCs [39]; p53 has been shown to harbour UV signature C>T and CC>TT transitions in approximately 50% of all skin cancers [37,42], but has a higher rate of A>T in melanoma compared to other skin cancers [39], further implicating UV damage. This evidence concerns the gene TP53 and melanoma.