PDLIM5 and acute lymphoblastic leukemia: 38 Within T-ALL, the lim-only proteins LMO1 and LMO2 are similarly expressed ectopically as a consequence of translocations involving T-cell receptor gene loci.24 Importantly, mouse models have shown that ectopic expression of either LMO1 or LMO2 is sufficient to cause the development of T-ALL,4, 39 thus proving that out-of-context expression of native LMO proteins represents a leukaemogenic event during T-ALL development.