Moreover, Scl/Tal1 has previously been shown to interact with the T-lymphoid GATA factor GATA3 within T-ALL cells,11, 35 thus suggesting possible joint regulation of LMO1 by SCL/TAL1 and GATA3 acting through the LMO1 +57 enhancer. Here, GATA3 is linked to acute lymphoblastic leukemia.