LYL1 and acute lymphoblastic leukemia: Moreover, as SCL, LMO2 and LYL1 have all been identified as T-ALL oncogenes in human patients28, 29, 30 and Erg has been shown to cause T-ALL in mouse models,31 binding of these factors in a myeloid progenitor cell line suggested that some of these factors may also act on the LMO1 +57 enhancer in LMO1-expressing T-ALL cells.