The presence of a highly conserved region downstream of LMO1 that was bound by multiple transcription factors in haematopoietic cells prompted us to investigate the possible involvement of this genomic region in ectopic expression, particularly since several of the transcription factors bound to this region in stem/progenitor cells were known T-ALL leukaemia oncogenes (for example, SCL/TAL1 and LYL1). The gene discussed is LYL1; the disease is acute lymphoblastic leukemia.