To assess possible involvement of SCL/TAL1 and GATA3, we performed ChIP assays using T-ALL cells from primagraft X31 using previously validated antibodies against SCL/TAL127 and GATA3.36 (Figure 6d) Analysis of ChIP material by quantitative PCR demonstrated significant binding of both SCL/TAL1 and GATA3 to the LMO1 +57 enhancer, but not to either of the two LMO1 promoters. Here, TAL1 is linked to acute lymphoblastic leukemia.