Taken together therefore, these observations are consistent with a model whereby LMO1 forms part of a core T-ALL regulatory circuit that involves other T-ALL oncogenes such as SCL/TAL1 and within which, the LMO1 +57 enhancer has a central role integrating inputs from upstream regulators to mediate ectopic LMO1 expression. Here, TAL1 is linked to acute lymphoblastic leukemia.