Taken together therefore, these observations are consistent with a model whereby LMO1 forms part of a core T-ALL regulatory circuit that involves other T-ALL oncogenes such as SCL/TAL1 and within which, the LMO1 +57 enhancer has a central role integrating inputs from upstream regulators to mediate ectopic LMO1 expression. The gene discussed is LMO1; the disease is acute lymphoblastic leukemia.