The PALB2 c.2323C>T mutation, which results in the introduction of a stop codon at amino acid position 775 (p.Q775X), has been reported in at least three French Canadian breast cancer families[5], and along with other protein truncating PALB2 mutations found in breast cancer cases, is strongly suspected to be deleterious[17]. The gene discussed is PALB2; the disease is breast cancer.