MT-ND4 and age-related macular degeneration: Our results support previous findings that the haplogroup T-associated SNP A4917G is an independent predictor of AMD [17] and two variants of the T2 haplogroup, A11812G of MT-ND4 and A14233G of MT-ND6, are 2.5 times more likely to be associated with advanced AMD than the age-matched control subjects [19].