In support with this, a subset of melanoma stem/progenitor cells expressing stem cell-like markers such as CD133, nestin, neural crest nerve growth factor receptor CD271, Oct-3/4, Nanog, multi-drug resistance protein-1 (MDR1), ABCG2 and/or ABCB5 has been isolated from human primary and metastatic melanoma specimens or melanoma cell lines [83, 161–165]. The gene discussed is NES; the disease is melanoma.