For instance, the ETBR blockage using a pharmacological antagonist, A-192621 resulted in a decrease in HIF-1α and HIF-2α stability concomitant with an increase in prolyl hydroxylase domain protein 2 level that was accompanied by an inhibition of tumour growth and angiogenesis of human M10 melanoma cell-derived xenografts in nude mice [176]. Here, EPAS1 is linked to melanoma.