HIF1A and melanoma: It has also been noticed that the expression of a HIF-1α785 isoform lacking a part of the oxygen regulation domain and which is more stable than full-length HIF-1α under high oxygen tension, was also induced by 12V-H-Ras, hyperthermia, serum, EGF, phorbol 12-myristate 13-acetate (PMA), heat and oxidative stresses in melanoma cell lines under normoxic conditions [178, 181].