IGF1R and familial pancreatic carcinoma: Other potential strategies for eradicating pancreatic cancer stem/progenitor cells and their progenies and reversing treatment resistance, may consist of targeting Ras mutant, EGFR, IGF-1R, PI3K/pAkt and EMT process-associated molecules, altered metabolic pathways and autophagy under normoxic or hypoxic conditions [29, 30, 51, 63, 284, 292–296].