It has also been shown that HIF-2α can play key roles in GSCs found within perinecrotic/hypoxic niche by inducing enhanced expression of specific tumour stem cell signature genes, including mastermind-like protein 3 (Notch pathway), nuclear factor of activated T cells 2 (calcineurin pathway) and aspartate β-hydroxylase domain-containing protein 2 that are associated with a poor prognosis of GBM patients [147]. Here, EPAS1 is linked to neoplasm.