Interestingly, it have also been observed that GSCs expressing stem cell-like markers CD133, Oligo-2, Oct-3/4, Sox-2, Nanog, Musashi and Bmi-1 from human glioblastoma biopsy specimens xenografted into brains of immunocompromised mice secreted high levels of VEGF, which were promoted under hypoxia, and generated highly vascularized tumours with areas of necrosis and haemorrhage [149]. The gene discussed is SOX2; the disease is neoplasm.