In the same way, the inhibition of HIF-1α by a novel selective inhibitor PX-478 was also effective at potentiating the cytotoxic effects induced by fractioned radiation treatment, with or without combined treatment with gemcitabine, on in vitro and in vivo human PANC-1, CFPAC-1 or SU.86.86 pancreatic cancer models at least in part by reversing radiation resistance of these hypoxic tumour cells and inhibiting the pro-angiogenic effect of HIF-1α [11]. Here, HIF1A is linked to familial pancreatic carcinoma.