On the other hand, high level of HIF-1α has also been detected in melanoma cells expressing melanoma antigen recognized by T cells-1 MART-1+ found in perivascular regions within tumour as well as MART-1− non-haematopoietic melanoma-associated stromal cells, including CD146+ pericytes associated with CD31+ endothelial cells and Sca-1+ stromal cells in a mouse model of melanoma [182]. This evidence concerns the gene TBXT and melanoma.