MGLL and pachyonychia congenita: Particularly, the data from global transcriptional profiling have revealed that the activity of monoacylglycerol lipase (MAGL), which plays a major role in lipogenesis in metastatic PC cells by converting monoglycerides to free fatty acids, was higher in AI and metastatic PC3 and DU145 cells relative to androgen-dependent LNCaP cells and associated with a gene signature that correlated with the EMT programme and stem cell-like properties of PC cells [234].