In the same way, it has also been observed that the down-regulation of HIF-1α by small hairpin RNA (shRNA) or using a HIF-1α inhibitor, echinomycin eradicated mouse lymphoma-initiating cells and human acute myeloid leukaemia (AML)-LSCs in both in vitro colony formation assays and in vivo mouse models, whereas normal HSCs were 100-fold less sensitive to echinomycin than lymphoma CSCs in vitro [134]. This evidence concerns the gene HIF1A and lymphoma.