ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Moreover, it has been shown that a natural product of Micromonospora strain designated as Rakicidin A, which acts as a hypoxia-selective cytotoxin, was effective at inducing the apoptotic death of TKI-resistant and hypoxia-adapted BCR-ABL+ CML cells endowed with stem cell-like properties maintained in suspension under low-oxygen conditions for more than 6 months [56].