CCND1 and neoplasm: On the other hand, the up-regulation of β-catenin (rank >7 folds) was significantly associated with high grade tumors (P = 0.049) and over-expression of CyclinD1 (P = 0.009) but there was no significant correlation with tumor stages (P = 0.189) and metastasis (P = 0.345) (Table 2).