In addition, CCAM showed that the subtypes AML with t(15;17) and AML with t(8;21) were more related to Neutrophil, which is consistent with their morphological associations with the granulocytic lineage: AML with t(15;17) has the PML-RARA fusion gene and corresponds to the FAB M3 subtype (acute promyeolocytic leukaemia) 46,47; AML with t(8;21) has the fusion gene AML1(RUNX1)/ETO and corresponds to the AML-M2 (acute myeloid leukaemia with maturation) [48]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.