However, sigmoidal fitting of the data revealed that the voltage dependence of STOC frequency was unaffected (voltage of half maximum activation, V50: −20.1±0.9, and −17.9±2.9 mV, in 9 control and 8 db/db CASMCs, respectively), suggesting that voltage sensitivity of BK channel activation is unaltered in type 2 diabetes. The gene discussed is KCNMA1; the disease is type 2 diabetes mellitus.