PPARA and carcinoma: The differential expressed genes in adenoma were enriched in 9 functional pathways including ribosome, cell adhesion molecules, and peroxisome proliferator-activated receptors (PPAR) signaling pathway (p<0.01) while the differential expressed genes in carcinoma were enriched in 24 pathways (p<0.01) (Table S3 and S4) by using the KEGG pathway analysis tool [22].