Although groups on different dietary regimen did not differ significantly in sRAGE levels, formula-consuming infants, particularly those administered high-CML-containing formulas, presented a positive relationship between total plasma CML and sRAGE concentrations, probably reflecting the enhanced cleavage of sRAGE from the cell surface RAGE. The gene discussed is AGER; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.