Although the 5′ end of the NRG1 gene, including the HapICE haplotype and other haplotypes nearby, has been shown to be significant in different ethnic schizophrenia SCZ populations, our study supported the role of the 3′ end of the NRG1 gene on the prevalence of schizophrenia in European populations, a finding which has been suggested in only a few studies to date. The gene discussed is NRG1; the disease is schizophrenia.