CCL2 and Stroke: Whereas all investigated chemokines were found to be unchanged in their acute response at 12 h after stroke (TREM2-KO vs. WT), the increased expression of CCL3 and CCL2 was attenuated in TREM2-KO mice at 7 d after stroke (CCL3: to 12% ±1.3, CCL2: to 37% ±6.5, p≤0.05, n = 5/6 each; Figure 3A).