Whereas CCR1, CCR2 and CCR5 expression was found to be unchanged, a reduced gene transcription of the microglial-associated chemokine receptor CX3CR1 was observed after stroke in TREM2-KO mice compared to littermate control mice (12 h: to 79% ±6.7; 7 d: to 50% ±4.6, p≤0.05, n = 5/6 each; Figure 3B). Here, TREM2 is linked to stroke disorder.