NPM1 and anaplastic large cell lymphoma: This was noted by Rikova, et al., who elegantly proved that a chromosomal translocation produced a hybrid ALK-EML4 gene in a subset of cases, creating an oncogene analogous to nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which drives anaplastic large-cell lymphomas [24], [34], [35].