PTPN11 and cancer: Moreover, ChIP-chip assays yielded a total of 48 genes enriched in at least three of the seven primary samples including genes associated with cell cycle such as ARGHEF2, CCNA2, CDKN2D, GAK2, ORCL6, PCPNP, and TACC1 and genes associated with cancer such as AR, AXIN2, IKBKG, ETS1, PTPN11, and WNT2B (Figure 2).