In addition, in human erythroleukemia (HEL) cells, which are homozygous for the V617F mutation in JAK2 [25], high expression of c-Myc and ODC was observed, and treatment with AG490 diminished the phosphorylation of JAK2 and STAT5, and also the expression of c-Myc and ODC (Fig. 1F). This evidence concerns the gene JAK2 and erythroleukemia.