It was also noteworthy that the expression of Axin1 mRNA was reduced in breast cancer, and this reduction accelerated the oncogenic activity of c-Myc [42], [43]; however, our current analysis of the DNA array showed that alteration of the expression level of Axin1 mRNA was not found in JAK2 (V617)-induced transformation (data not shown). Here, AXIN1 is linked to breast carcinoma.