The immunofluorescence staining for K18, K14 and SMA in those tumors revealed that shFGFR2-transduced cells containing enriched non-TIC populations generated the breast tumors with markedly reduced numbers of bipotent precursor-like cells (K18+K14+) and increased numbers of myoepithelial cells (K18−K14+ and SMA+) (Figure S3A and S3B), compared to the shNT-transduced tumors, indicating terminal differentiation of a majority of tumor cells into myoepithelial lineages in tumors in vivo, in accordance with the observation in vitro (Figure 5D and 5E). The gene discussed is SMN1; the disease is neoplasm.