Although we found one SNP, rs1047100 (696A→G) in exon 6 of FGFR2 in 60% of the 30 primary human breast tumors analyzed, we failed to detect any of the previously described FGFR2 somatic mutations in either 30 primary human breast tumors or in MMTV-PyMT tumors (unpublished data), suggesting that FGFR2 somatic mutations may be an infrequent event in breast cancer. This evidence concerns the gene FGFR2 and breast neoplasm.