NCOA2 and hyperinsulinemic hypoglycemia, familial, 4: We suggest that this loss of regulation results from an inability of the SRC-2 KO mice to meet the energetic demands of cardiac hemodynamic overload since they are already relying on an altered metabolic pathway (Fig. 2) and that this results in an ATP deficiency upon TAC, leading to inhibition of hypertrophy and decreased cardiac function.