To support that CD11b−CD103+ DCs indeed may prime airway allergy in vivo, the same authors reported that BXH2 mice, which lack CD103+ DCs due to a point mutation in the interferon (IFN) regulatory factor (Irf)8 gene [14], are protected from airway allergy induced by endotoxin-adjuvanted ovalbumin (OVA) and house dust extracts [13]. Here, ITGAE is linked to allergic respiratory disease.