Recently, some studies focused on the effects of K5 on cell motility such as recruitment of tumor-associated macrophages [14], endothelial cell migration [15], aggregation of inflammatory cells [9] and neutrophil infiltration [16], suggesting a significant association between the biological activity of K5 and the regulation of cell motility in endotheliocytes and other cells. This evidence concerns the gene KRT5 and neoplasm.