We observed that the expression of DIAB2IP, a metastasis suppressor and a target of EZH2-mediated epigenetic silencing in prostate cancer [45], [46], was increased significantly upon EZH2 knockdown, suggesting a potential role of DIAB2IP in regulating Ras-signaling in lung epithelia cells, and its inactivation as part of the oncogenic process in the lung. This evidence concerns the gene EZH2 and Familial prostate cancer.