Furthermore, we also observed that expression of caspase 3, apoptotic markers cleaved PARP Asp214 and cleaved caspase-3 Asp175 were increased in A549 cells with EZH2 knockdown (Fig. 4B), suggesting EZH2 overexpression could have anti-apoptosis function in some NSCLC cells. The gene discussed is EZH2; the disease is non-small cell lung carcinoma.