In neuroblastoma, the cooperative proapoptotic effect of DOX and PI103 resulted in upregulation of Noxa and Bim, which correlated with increased Bax/Bak conformational change, loss of mitochondrial membrane potential, cytochrome c release, caspase activation, and caspase-dependent apoptosis [25]. The gene discussed is BCL2L11; the disease is neuroblastoma.