NOD2 and Cowden disease: We could not identify a specific IBD phenotype associated with the SNPs rs4495224 and rs7720838, although the cohort used in this study convincingly demonstrated other strong association such as for the NOD2 variant p.Leu1007fsX1008 with ileal CD involvement, stenosis and need for surgery [16], [17], [56], [57], suggesting that the sample size in CD was sufficient to detect clinically relevant associations.