Very recently, the largest meta-analysis ever performed in IBD, including more than 75,000 cases and controls, demonstrated an association with UC, which convincingly confirms that there is a very strong association of the PTGER4 locus with CD (p = 1.81×10−82), while there is only a weak association with UC (p = 1.68×10−5 for the immunochip UC cohort) which reached only in all UC cohorts combined genome-wide significance (p = 1.36×10−10 for all UC cohorts combined) [37]. The gene discussed is PTGER4; the disease is inflammatory bowel disease.