We examined the associations between the frequencies of IFNγ-IL2+TNF−, IFNγ-IL2+TNF+, and IFNγ-IL2-TNF+ T cells and T cells expressing at least TNF or at least IL2 on stimulation with CSP and subsequent risk of clinical malaria in the 6 months that followed the measurement. The gene discussed is TNF; the disease is malaria.