Thus, we identified a phenotype of MICs characterized by the expression of specific MMPs and TIMPs (MMP-2, 9 11 and 14, and with TIMP-2) in the tumor center, associated with distant metastasis development [25]–[26], suggesting that inflammatory cells at the invasive front can polarize their phenotype impacting on tumor progression [27]. The gene discussed is MMP2; the disease is neoplasm.