Thus, in the present work we determined the expression of these significant proteins (MMP-2, 9, 11, 14, and TIMP-2) in the tumor samples, and analyzed the possible relationship between the presence of different MICs phenotypes at the invasive front, and MMPs and TIMPs expressions by tumors both in the invasive front and in the tumor center. The gene discussed is TIMP2; the disease is neoplasm.