DNM2 and neoplasm: The aim of our study was thus first to establish an in vitro endothelial cell system in which cultured adherent endothelial cells of microvascular origin were used to mimic tumour endothelium, and secondly to evaluate the ECT-induced changes in endothelial cell monolayer permeability, cell morphology and cytoskeletal proteins to further elucidate mechanisms involved in ECT-induced vascular disruption in tumours.