In order to investigate the effect of cytoplasmic p-Akt1 expression on the survival of invasive breast carcinoma patients with low or high cytoplasmic Skp2 expression, all patients with invasive breast carcinoma were categorized into low or high cytoplasmic p-Akt1 expression groups, and the Kaplan-Meier curve and log-rank test were applied to each group. The gene discussed is AKT1; the disease is invasive breast carcinoma.