Multivariate analysis showed that cytoplasmic Skp2 expression (HR = 1.662, 95% CI 1.027–2.690, p = 0.039) parallels prognostic indicators of metastasis, as do tumor size (HR = 1.164, 95% CI 1.063–1.274, p = 0.001) and lymph node status (HR = 3.835, 95% CI 2.158–6.813, p = 0.000). This evidence concerns the gene SKP2 and neoplasm.