Moreover, some of these connections were directly or indirectly associated with concordant genes previously related to neuronal development such as muscle segment homeobox (msh) 2 (MSX2), megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1), RUNX3, catenin delta-2 (CTNND2), receptor tyrosine kinase (AXL), neuronatin (NNAT), and NRN1[24]–[30] (Fig. 5). This evidence concerns the gene RUNX3 and megalencephalic leukoencephalopathy with subcortical cysts.