When compared with the ALS Online genetics Database (ALSoD)-reported genes and other ALS-dependent methylation/gene expression of profiling studies [39], [41], [68]–[72], we observed a modest overlap of four concordant epigenes; Purkinje cell protein 4 (PCP4), catenin (CTNNAL1), fibroblast growth factor 18 (FGF18), and flavin containing monooxygenase 1 (FMO1). The gene discussed is CTNNAL1; the disease is amyotrophic lateral sclerosis.