A1AT is an acute-phase serine proteinase inhibitor with a broad anti-inflammatory spectrum and it has been suggested that it controls the inflammatory component of musculoskeletal connective tissue associated with fibromyalgia [50].The results from two independent series of genotyping 3127 subjects for A1AT supported the hypothesis that the 13% of persons carrying A1AT polymorphisms may represent almost 40% of all cases of fibromyalgia [51]. The gene discussed is SERPINA1; the disease is fibromyalgia.