Similar to the SNP-based findings, the RECQL4 region had the strongest association with the risk of melanoma (gene-based P-value = 2.5×10−3; Table 2, Table S2 and Figure S2) and the RTEL1 region had the strongest association with risk of dysplastic nevi (gene-based P-value = 0.004; Table 3, Table S3 and Figure S4). This evidence concerns the gene RTEL1 and dysplastic nevus.