Similar to the gene-based results, the helicase subgroup, which included the RECQL4 region, was associated with melanoma risk (P = 0.03); a telomere related group, which included the RTEL1 region, was associated with dysplastic nevi (P = 0.11); and the shelterin subgroup, which included the TERF2 region, was associated with nevus count (P = 0.09). The gene discussed is RTEL1; the disease is melanoma.