It has been shown that the NT can mediate self-association and confers the cross-linking properties of Gal-3; the CRD can bind glycol-ligands and confers the lectin activities of Gal-3; the LD governs Gal-3 secretion and nuclear localization; and the RD harbors the cleavage sites for collagenases and matrix metalloproteinases and is relevant to tumor growth and angiogenisis [2], [17], [19]. Here, LGALS3 is linked to neoplasm.