While the authors of the p.Arg150Gln work concluded after demonstrating the absence of the mutation in 200 sporadic breast cancers and in 100 colon cancers that the RAD51 p.Arg150Gln substitution was likely to be the disease-causing mutation, we could not confirm those findings, as we found no difference in occurrence of this mutation between cases and controls. The gene discussed is RAD51; the disease is breast cancer.