Yet another possibility is a translocation-mediated change in chromatin, which could impact on the expression of the nearby gene, ING3 that is located just 13 Kb upstream of C7orf58. Most interestingly, the protein encoded by ING3 contains a PHD-finger domain, a common motif involved in chromatin remodeling genes [36] that are increasingly being recognized as target genes for developmental disorders, such as recently in Potocki-Shaffer-syndrome, which is caused by disruption of a BRAF-histone deacetylase gene [37]. Here, BRAF is linked to Potocki-Shaffer syndrome.