Our results show that luteolin could significantly inhibit VEGF-stimulated endothelial cell proliferation, chemotactic migration, invasion, tube formation, and tumor angiogenesis by targeting VEGFR-2-regulated AKT/ERK/mTOR/P70S6K/MMPs pathway, leading to the suppression of prostate tumor growth and tumor angiogenesis. This evidence concerns the gene RPS6KB1 and neoplasm.