LDLR and atherosclerosis: [5] While T-cell specific loss of SOCS-3 resulted in reduced plaque development, the role of SOCS-1 in atherosclerosis has not been determined yet. [5], [6] Therefore, we investigated the impact of a systemic deficiency of SOCS-1 on atherogenesis in the established, murine low-density lipoprotein receptor (LDLR) model of atherosclerosis.