As demonstrated by differential blood counts, Ldlr−/−;Rag-2−/− and Socs-1−/−triple-KO mice displayed a significant leucopenia that was compensated in Socs-1−/−triple-KO mice by granulocytosis, resulting in similar total circulating leukocyte numbers compared to Ldlr−/− mice. The gene discussed is LDLR; the disease is Increased total granulocyte count.