MYH9 was an excellent candidate disease gene at this locus for several reasons, the foremost of which is that rare autosomal dominant mutations in MYH9 can cause glomerulosclerosis in patients with Epstein's Syndrome and Fetchner's Syndrome, in which patients usually reach end stage kidney disease during their 3rd–4th decade of life [4], [5]. Here, MYH9 is linked to macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.