MYH9 and glomerulosclerosis: MYH9 was an excellent candidate disease gene at this locus for several reasons, the foremost of which is that rare autosomal dominant mutations in MYH9 can cause glomerulosclerosis in patients with Epstein's Syndrome and Fetchner's Syndrome, in which patients usually reach end stage kidney disease during their 3rd–4th decade of life [4], [5].