In this study we use classical genetic inference, starting from the premise that the G1 and G2 alleles of APOL1 correlate with glomerulosclerosis best in a recessive model, , with a similar risk for FSGS in homozygous or compound heterozygous individuals (G1/G1, G2/G2, or G1/G2), with an Odds Ratio that ranges from 6.7 up to 16.9 in the most recent study [12], [13], [30]. This evidence concerns the gene APOL1 and focal segmental glomerulosclerosis.