When APOL1 G1 and G2 alleles are accounted for, the strength of the correlation between MYH9 SNPs and African-American kidney disease is either significantly reduced [13], [14], or effectively eliminated [12] due to linkage between APOL1 and MYH9. In addition, analysis of the worldwide distribution of MYH9 polymorphisms demonstrated that the high allele frequency of the MYH9 ”risk haplotype” among African-Americans and West Africans could be accounted for by linkage with a nearby site of selection, such as within APOL1[15]. The gene discussed is APOL1; the disease is kidney disorder.