Deletion of Myh9 from podocytes in experimental mice resulted in a predisposition to glomerulosclerosis in response to injury, which mimicked the predisposition to kidney disease among African-Americans with MYH9 “risk alleles [11],” but the uncertainty of MYH9 as the causal gene for African-American glomerulosclerosis remained. Here, MYH9 is linked to kidney disorder.