APOL1 and glomerulosclerosis: Finally, whether implicating autophagy or any other mechanism mentioned above to explain glomerulosclerosis, one must explain why this occurs only with the G1 and G2 variants and not with wild type APOL1. In short, while G1 and G2 may cause glomerulosclerosis through increased autophagy, there are very little data in support of this at present.