IGF1 and neoplasm: We have focused on the IGF-1/IGF-1R pathway because the activation of this pathway is important in PCa, the abundant expression of IGF-1 [42] in osteoblasts leads to frequent activation of IGF-1R in tumor cells [43], [44] and because IGF-1R may signal through compensatory pathways that blunt the effectiveness of Src inhibitors such as dasatinib.