In contrast, our findings revealed that p53 overexpression and stabilization reduced TNF-activated IκB (Figure 3C, 6B, S1B and S2) but had no effect on IKK expression (Fig. 5C, S1C and S2), suggesting that p53 is unlikely to affect IKK as an upstream target for phosphorylation of IκB in ovarian cancer cells. This evidence concerns the gene TNF and ovarian cancer.