Intriguingly, we found that Capn3 E6- expression correlates with the degree of muscular dystrophy in different muscles and at different ages (Figure 2 and Figure 3) suggesting that altered Capn3 E6- could explain the differential susceptibility of different muscles to FRG1 over-expression and the progression of the disease over time. Here, FRG1 is linked to muscular dystrophy.