Importantly, this excluded transient receptor potential cation channel, subfamily V, member 1 (Trpv1) at 73.0 Mb (73047794–73074744) underlying Idd4.1, a quantitative trait loci (QTL) controlling susceptibility to type 1 diabetes in the NOD mouse [11], and inducible nitric oxide synthase (Nos2/iNos), important in inflammatory diseases including autoimmunity [12], [13], as candidate genes for Orch3. Nlrp1a/b/c is one of two highly polymorphic positional candidate loci of immunological relevance within the interval, the second gene being kinesin family member 1C (Kif1c). This evidence concerns the gene NOS2 and type 1 diabetes mellitus.