Importantly, this excluded transient receptor potential cation channel, subfamily V, member 1 (Trpv1) at 73.0 Mb (73047794–73074744) underlying Idd4.1, a quantitative trait loci (QTL) controlling susceptibility to type 1 diabetes in the NOD mouse [11], and inducible nitric oxide synthase (Nos2/iNos), important in inflammatory diseases including autoimmunity [12], [13], as candidate genes for Orch3. Nlrp1a/b/c is one of two highly polymorphic positional candidate loci of immunological relevance within the interval, the second gene being kinesin family member 1C (Kif1c). The gene discussed is NOS2; the disease is Autoimmunity.