Our current study and previous data support the notion that BubR1 protein levels tightly correlate with aneuploidy rates, cancer susceptibility, lifespan and aging-related phenotypes (Table S1), indicating that BubR1 is a key determinant of healthspan and lifespan and warrants a comprehensive analysis of the health status of parents of MVA patients and relatives that are also heterozygous carriers of the same MVA BUBR1 mutations. Here, BUB1B is linked to cancer.