MVA syndrome has been documented as a hereditary cancer syndrome [15]–[18], [25]–[27], but could potentially be classified also as a progeroid syndrome based on its phenotypic resemblance to BubR1 progeroid mice, which includes short lifespan, dwarfism, facial dysmorphisms, and cataract formation. Here, BUB1B is linked to mosaic variegated aneuploidy syndrome 1.