MAPT and early-onset autosomal dominant Alzheimer disease: We use this approach to investigate how the proteins of the human influenza virus interfere with the immune response of the host cell in a tissue-specific manner, finding novel potential regulators of influenza virus pathogenicity, and to study the brain-specific signaling pathways that play a role in Alzheimer's disease, identifying a pathway involving the altered phosphorylation of the Tau protein.