HLA-DRA and multiple sclerosis: Figure 5 shows one illustrative PheWAS plot of phenotype associations with an HLA-DRA SNP known to be associated with multiple sclerosis. Of note, this PheWAS not only demonstrates a strong association between this SNP and multiple sclerosis, but also highlights other possible associations, such as Type 1 diabetes and acquired hypothyroidism. Recent explorations into PheWAS methods using NLP have shown greater efficacy for detecting associations: with the same patients, NLP-based PheWAS replicated six of the seven known associations, generally with more significant p-values [80].