Clustering of the NKI-295 set [29], using the direct transcriptional targets of ELF5, distinguished the intrinsic subtypes and produced a clear separation of tumor characteristics such as poor prognosis, early metastasis, early death, recurrence, survival, grade, mutation status, and marker expression, such as ER and PR (Figure S15C). The gene discussed is ELF5; the disease is neoplasm.