CHFR and ovarian cancer: Upregulated genes included RB1CC1 (promotes RB1 expression), TBRG1 (promotes G1 arrest via CDKN2A), IRF1 (initiates interferon response), COPS2 (p53 stabilizer), CHFR (prevents passage into mitosis), DAB2 (lost in ovarian cancer), and RAD50 (DNA damage checkpoint).