Phosphorylation of IκB by upstream kinases promotes its ubiquitination-dependent degradation, allowing NFκB to translocate to the nucleus and induce target genes, which is associated with cell proliferation [24], angiogenesis [25], metastasis [26], suppression of apoptosis [27], promotion of oncogenesis [28], and cancer therapy resistance [24]. Here, NFKB1 is linked to cancer.