Interestingly, curcumin and emodin, which are natural anthraquinone derivatives found in the roots and rhizomes of numerous plants, were found to enhance cisplatin-induced cytotoxicity via downregulation of ERCC1 and inactivation of ERK1/2 in non-small cell lung cancer [52]. The gene discussed is ERCC1; the disease is non-small cell lung carcinoma.