INS and type 2 diabetes mellitus: In healthy volunteers (n=22), with (OffT2D: n=15) and without (n=7) a family history of type 2 diabetes mellitus, fed a control diet, there was no association between circulating PCSK9 concentrations and both whole-body (i.e., GIR: glucose infusion rate) and hepatic (HGP: hepatic glucose production) insulin sensitivity (Table1).