ADORA2A and Parkinson disease: In a rodent models of PD, A2A adenosine receptor antagonists increased locomotor activity in MPTP-treated or reserpinized mice, reversed haloperidol-induced catalepsy in rats (Shiozaki et al. 1999; Hauber et al. 2001) and potentiated rotational behavior produced by l-DOPA or dopamine agonists in 6-OHDA-lesioned rats (Fenu et al. 1997; Rose et al. 2007).